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KMID : 0363320060270020327
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Journal of Korean Oriental Internal Medicine
2006 Volume.27 No. 2 p.327 ~ p.335
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The Effects of Hominis Placenta Hydrate (HPH) on the Bone Marrow Failuer Induced by 5-Fluorouracil
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Shin Jang-Woo
Cho Jung-Hyo
Son Chang-Gue
Lee Yong-Yeon
Lee Yeon-Weol
Yoo Hwa-Seung
Lee Nam-Heon
Yun Dam-Hee
Cho Chong-Kwan
Choi Chang-Woo
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Abstract
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Aim: To examine the efficacy of Hominis Placenta Hydrate (HPH) on the hemopoiesis in a myelosuppression model system.
Methods: Mice were injected with 5-Fluorouracil (5-FU) intraperitoneally and were administered with 200 mg/kg and 1000 mg/kg of HPH. Peripheral blood was analyzed at 5, 9, and 13 days. Histopathologic examination of bone marrow was performed at 5 days after 5-FU injection. The expression of cytokine involved in hemopoiesis was examined by using ELISA kit.
Results: The hematology data demonstrated that the treatment of all the agents augmented monocytes and leucocytes counts in the peripheral blood WBC and platelet in HPH treated group were significant increased compared with control group. Also, cell numbers of RBC and Hb were restored. In HPH treated group, expression of IL-3, GM-CSF was significant increased But not TPO.
Conclusions: Based on the above results, it is suggested that Hominis Placenta Hydrate is an effective remedy for the bone marrow failure and myelosuppression occurring during chemotherapy.
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KEYWORD
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Hominis Placenta hemopoiesis, IL-3, GM-CSF
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